TD-HY339010

Iv0120 is a monoclonal antibody that targets human Arginase 1 (hArg1), a metalloenzyme that hydrolyzes L-arginine to L-ornithine and urea and modulates T cell–mediated immune responses. Iv0120 binds over the active site opening, sterically blocking hArg1 activity.

Human

ELISA, FCM, Neutralization

Mouse

IgG2a, kappa

Iv0120

Monoclonal

Liver-type arginase, ARG1, Type I arginase, Arginase-1

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P05089

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Detects Human ARG1/Arginase-1 in indirect ELISAs.　　|　　Flow-cytometry using anti-human Arginase 1 antibody.M2 macrophages derived from THP-1 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human Arginase 1 antibody monoclonal antibody (Catalog No.:TD-HY339010 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog No.:TD-MF690414) and cells analysed on a NovoCyte Flow Cytometer.,Flow-cytometry using anti-human Arginase 1 antibody.Human peripheral blood lymphocytes were stained with an irrelevant antibody (Blue Histogram) or an anti-human Arginase 1 antibody monoclonal antibody (Catalog No.:TD-HY339010 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog No.:TD-MF690414) and cells analysed on a NovoCyte Flow Cytometer.　　|　　SDS-PAGE for InVivoMAb Anti-Human ARG1/Arginase-1 Antibody (Iv0120).　　|　　Flow-cytometry using PE anti-human Arginase 1 antibody. HepG-2 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human Arginase 1 monoclonal antibody (Catalog No.:TD-HY339010, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

For research use only. Not suitable for clinical or therapeutic use.