Cat. #: TD-26151 |
Gene Symbol: ALK, CD246, NBLST3 |
Description: Anti-ALK(R1275Q) Mouse Monoclonal Antibody |
Background: Anaplastic lymphoma kinase (ALK) also known as CD246 (cluster of differentiation 246) is a tyrosine kinase receptor that plays an important role in the development of the brain and nervous systems. Deficiencies in ALK, which most commonly as a fusion with other genes, are indicated in cancers. |
Immunogen: A synthetic peptide from the internal region of ALK which includes the mutation of R1275Q, human origin. |
Applications: ELISA, WB, IHC |
Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:100-1:1000 IHC: 1:50-1:100 |
Concentration: 0.5 mg/ml |
Host Species: Mouse |
Format: Liquid |
Clonality: Monoclonal |
Isotype: IgG |
Purity: Purified from ascites |
Preservative: No |
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
Species Reactivity: Recognizes ALK(R1275Q), but not wild type ALK protein from vertebrates. |
Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot:
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Western blot analysis of recombinant ALK(R1275Q) and wild type proteins. Purified His-tagged ALK(R1275Q) protein (amino acids 1060-1620, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-ALK(R1275Q) mouse monoclonal antibody (Cat. #TD-26151). |