TD-VK515046

Gedivumab(TD-VK515046) is a research-grade recombinant antibody targetingHA/Hemagglutinin. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Influenza A virus

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1, kappa

Monoclonal

HA/Hemagglutinin

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

C6KNH7

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

MHAA4549A, RO6876802, RG7745, 1807954-17-1

Gedivumab (MHAA4549A; RG7745) is a human monoclonal antibody that targets influenza A virus (IAV) with high specificity and binds to the highly conserved stem region of the IAV haemagglutinin protein, thereby preventing haemagglutinin maturation and blocking haemagglutinin-mediated membrane fusion in the intranucleosome. Gedivumab can be used in IAV infection disease studies.• SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity., PMID:31913745• KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity., PMID:35266843• Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression., PMID:35253629•Streptococcus pneumoniaeextracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin)., PMID:38497494• Engineered Macrophage Membrane-Coated S100A9-siRNA for Ameliorating Myocardial Ischemia-Reperfusion Injury., PMID:39264262• Phosphorylation of ATG18a by BAK1 suppresses autophagy and attenuates plant resistance against necrotrophic pathogens., PMID:32804012• TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1., PMID:38009729• A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC., PMID:36300799• Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway., PMID:35130104• Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress., PMID:36719671

SEC-HPLC detection for Research Grade Gedivumab.　　|　SDS-PAGE for Research Grade Gedivumab.

For research use only. Not suitable for clinical or therapeutic use.