TD-MS870020

The RMP1-14 monoclonal antibody recognizes mouse PD-1 (CD279), a 50–55 kDa CD28-family receptor transiently expressed on thymocytes, activated T and B cells, and myeloid cells. PD-1 contains an ITIM motif and delivers inhibitory signals upon engagement with its ligands PD-L1 and PD-L2, reducing T-cell activation and promoting peripheral tolerance. PD-1 deficiency in mice leads to autoimmunity, while PD-L1 upregulation in tumors enhances resistance to CD8 T-cell–mediated killing. Blocking the PD-1/PD-L1 pathway can inhibit tumor growth in mouse models. RMP1-14, like J43, effectively blocks PD-1 binding to both PD-L1 and PD-L2.

Mouse

Neutralization

Mouse

IgG2a, kappa (Silence)

RMP1-14

Monoclonal

Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q02242

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

SDS-PAGE for InVivoMAb Anti-Mouse CD279/PDCD1/PD1 Antibody (RMP1-14)

For research use only. Not suitable for clinical or therapeutic use.