TD-HY235036

Gantenerumab(TD-HY235036) is a research-grade recombinant antibody targetingAICD-57. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1-kappa

Monoclonal

AICD-57, A4, Beta-CTF, Protease nexin-II, Gamma-CTF(50), ABPP, S-APP-beta, APP, Abeta40, Abeta42, AID(59), Amyloid intracellular domain 59, AID(57), S-APP-alpha, Gamma-CTF(59), Beta-secretase C-terminal fragment, Amyloid-beta precursor protein, Amyloid precursor protein, Beta-APP42, PreA4, Alzheimer disease amyloid protein, APPI, PN-II, AICD-59, Alpha-secretase C-terminal fragment, Amyloid-beta A4 protein, Amyloid intracellular domain 57, CVAP, Amyloid intracellular domain 50, Beta-APP40, AD1, Cerebral vascular amyloid peptide, AID(50), Alpha-CTF, Gamma-CTF(57), AICD-50

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P05067

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

R1450, 1043556-46-2

SEC-HPLC detection for Research Grade Gantenerumab.　　|　SDS-PAGE for Research Grade Gantenerumab.　　|　Flow-cytometry using anti-human APP antibody. SH-SY5Y cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an anti-human APP monoclonal antibody (Catalog HY235036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.　　|　Flow-cytometry using APC anti-human APP antibody. SH-SY5Y cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an APC anti-human APP monoclonal antibody (Catalog HY235036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer. ### Flow-cytometry using PE anti-human APP antibody. SH-SY5Y cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an PE anti-human APP monoclonal antibody (Catalog HY235036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer. ### Flow-cytometry using FITC anti-human APP antibody. SH-SY5Y cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human APP monoclonal antibody (Catalog HY235036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

For research use only. Not suitable for clinical or therapeutic use.