Congo Red
Synonyms: 刚果红
TD-D0236 纯度: ≥95.0%
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| 生物活性 |
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Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections. |
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体外研究
(In Vitro) |
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Congo Red histochemical stain may serve as a simple screening tool for investigating if the aggregates in mutant cells have misfolded β-pleated sheet secondary structures. Congo Red histochemical dye has the ability to bind specifically to crossed β-pleated sheet structures. Wild-type HSPB1 should maintain protein homeostasis by binding proteins in non-native conformations, thereby preventing substrate aggregation. The T139M mutant, however, fails in this function and results in an accumulation of misfolded proteins, which are targeted by Congo Red for intercalating between the β-pleated sheet structures. Congo Red histochemical stain may serve as a simple tool to investigate if the aggregates in mutant cells have misfolded β-pleated sheet secondary structures.
Tanda has not independently confirmed the accuracy of these methods. They are for reference only. |
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| Clinical Trial |
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NCT Number |
Sponsor |
Condition |
Start Date |
Phase |
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NCT02381210 |
Gynuity Health Projects|Nationwide Children´s Hospital |
Preeclampsia
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July 2016 |
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NCT02381197 |
Gynuity Health Projects|Nationwide Children´s Hospital |
Preeclampsia
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January 2017 |
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NCT02611011 |
Gynuity Health Projects |
Preeclampsia
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March 1, 2018 |
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NCT03966105 |
Oncology Institute of Southern Switzerland|University of Kiel|Ente Ospedaliero Cantonale, Bellinzona |
Wild-type Transthyretin Amyloidosis
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November 1, 2019 |
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NCT02610972 |
Gynuity Health Projects|International Centre for Diarrhoeal Disease Research, Bangladesh |
Preeclampsia
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December 1, 2018 |
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| 分子量 |
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696.66 |
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| Formula |
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C32H22N6Na2O6S2 |
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| CAS 号 |
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573-58-0 |
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| 性状 |
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固体 |
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| 颜色 |
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Pink to red |
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| 中文名称 |
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刚果红 |
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| 运输条件 |
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Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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4°C, sealed storage, away from moisture and light |
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*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| 溶解性数据 |
细胞实验： |
| DMSO 中的溶解度 : 20mg/mL (28.71 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO) |
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| 配制储备液： |
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溶剂体积 质量
浓度 |
1 mg |
5 mg |
10 mg |
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| 1 mM |
1.4354 mL |
7.1771 mL |
14.3542 mL |
| 5 mM |
0.2871 mL |
1.4354 mL |
2.8708 mL |
| 10 mM |
0.1435 mL |
0.7177 mL |
1.4354mL |
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。 |
抗体
试剂盒
多肽
探针
蛋白
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