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CD40 Mouse mAb
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ICC/IF
- Catalog： TD-220338
- Clonality： mAb
- Application： ICC/IF
- Synonyms： CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40
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规格：
100ul 50ul
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价格：
¥2680
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CD40 Mouse mAb
| Cat.# | TD-220338 |
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Product Name
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CD40 Mouse mAb
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Gene ID
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958
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SwissProt ID
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P25942
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Gene Name
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CD40
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Alternative Names
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CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40
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Background
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This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Research Field
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Immunology
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Product Categories
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Primary antibody
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Host
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Mouse
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Reactivity
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Human
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Application
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ICC/IF
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Dilution Ratio
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IF: 1/50-1/200
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Molecular Weight
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-
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Clonality
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Monoclonal Antibody
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Clonality No.
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9G10
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Isotype
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IgG1
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Immunogen
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Purified recombinant fragment of CD40 expressed in E. Coli.
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Purification
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Ascitic Fluid
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Conjugation
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Unconjugated
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Modification
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Unmodified
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Form
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Liquid
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Buffer System
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Ascitic fluid containing 0.03% sodium azide.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Immunofluorescence analysis of CD40 in Human peripheral blood lymphocyles (left) and mouse L121 cells (right) using CD40 antibody(green). Blue: DRAQ5 fluorescent DNA dye. |