TD-MB651010

The Iv0047 monoclonal antibody specifically targets mouse CTLA-4 (CD152), a 33-kDa inhibitory receptor of the CD28 family expressed on activated T and B cells. CTLA-4 interacts with the B7 ligands CD80 and CD86, delivering negative signals that regulate T-cell activation, maintain immune tolerance, and preserve homeostasis. The critical role of CTLA-4 is underscored by CTLA-4–deficient mice, which develop lethal lymphoproliferation. As an important immune checkpoint, CTLA-4 is a key target for cancer immunotherapy. The 9D9 antibody is widely employed to block CTLA-4 and has been shown in multiple tumor models to effectively deplete intratumoral regulatory T cells in vivo.

Mouse

ELISA, Neutralization

Mouse

IgG2b, kappa

Iv0047

Monoclonal

Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4, Cd152

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P09793

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

SDS-PAGE for InVivoMAb Anti-Mouse CD152/CTLA4 (Iv0047).

For research use only. Not suitable for clinical or therapeutic use.