抗体
试剂盒
多肽
探针
蛋白
组织芯片
产品中心
Product Center
Anti-SMAD4 (R361H) Mouse Monoclonal Antibody
All
TD-264221
TD-264222
- Catalog： TD-26422
- Clonality： mAb
- Application： ELISA, WB, IHC
- Synonyms： SMAD4(R361H)
-
规格：
100ul
-
价格：
¥4800
定制服务咨询
Anti-SMAD4 (R361H) Mouse Monoclonal Antibody
| Cat. #: TD-26422 |
| Gene Symbol: SMAD4, DPC4, JIP, MADH4, MYHRS |
| Description: Anti-SMAD4(R361H) Mouse Monoclonal Antibody |
| Background: SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-β signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiple colorectal cancers and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominant disease juvenile polyposis syndrome (JPS). |
| Immunogen: A synthetic peptide from the internal region of SMAD4 which includes the mutation of R361H, human origin. |
| Applications: ELISA, WB, IHC |
| Recommended Dilutions: ELISA: 1:1000-1:2000、WB: 1:500-1:1000、IHC: 1:50-1:100 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: |
| Purity: Purified from ascites |
| Preservative: no |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes R361H mutant, but not wild type SMAD4 of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
| Western blot:
Western blot analysis of recombinant SMAD4(R361H) and wild type proteins. Purified His-tagged SMAD4(R361H) protein (lane2) and corresponding wild type protein (lane1) were blotted with Anti-SMAD4(R361H) monoclonal antibody (Cat. #TD-26422).
|