The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Specification
Aliases
JAG1; AGS; AHD; AWS; HJ1; AGS1; JAGL1
Entrez GeneID
182
Swissprot
P78504
clone
7C7E1
WB Predicted band size
133.8kDa
Host/Isotype
Mouse IgG1
Antibody Type
Primary antibody
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human CD339 (AA: extra 47-212) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Application
WB
1/500 - 1/2000
FCM
1/200 - 1/400
ELISA
1/10000
Product Image
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of HL-60 cells using CD339 mouse mAb (green) and negative control (red).