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CD314
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ELISA
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FCM
- Catalog： TD-31916
- Clonality： mAb
- Application： WB, FCM
- Synonyms： KLRK1; KLR; NKG2D; NKG2-D; D12S2489E
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规格：
100ul 50ul
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价格：
¥2180
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Mouse Monoclonal Antibody to CD314
| Description | |
| Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. |
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| Specification | |
| Aliases | KLRK1; KLR; NKG2D; NKG2-D; D12S2489E |
| Entrez GeneID | 22914 |
| Swissprot | P26718 |
| clone | 5C9B4 |
| WB Predicted band size | 25.3kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human CD314 (AA: extra 73-216) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application | |
| WB | 1/500 - 1/2000 |
| FCM | 1/200-1/400 |
| ELISA | 1/10000 |
| Product Image | |
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng)
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Western blot analysis using CD314 mouse mAb against Rat Spleen (1), A549 (2), and HepG2 (3) cell lysate.
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Flow cytometric analysis of Jurkat cells using CD314 mouse mAb (green) and negative control (red).
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Flow cytometric analysis of THP-1 cells using CD314 mouse mAb (green) and negative control (red).
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