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CD45 Mouse mAb
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- Catalog： TD-220898
- Clonality： mAb
- Application： WB, IHC-P
- Synonyms： PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45
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规格：
100ul 50ul 20ul
-
价格：
¥2280
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CD45 Mouse mAb
| Cat.# | TD-220898 |
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Product Name
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CD45 Mouse mAb
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Gene ID
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5788
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SwissProt ID
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P08575
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Gene Name
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PTPRC
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Alternative Names
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PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45
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Background
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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
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Research Field
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Immunology
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Product Categories
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Primary antibody
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Host
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Mouse
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Reactivity
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Human,Mouse
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Application
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WB,IHC-P
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Dilution Ratio
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WB: 1/500-1/1000 IHC: 1/50-1/100
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Molecular Weight
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Calculated MW: 147 kDa; Obs/erved MW: 180-240kDa
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Clonality
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Monoclonal Antibody
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Clonality No.
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5D3A3
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Isotype
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IgG1
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Immunogen
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Purified recombinant fragment of human PTPRC expressed in E. Coli.
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Purification
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Affinity Purified
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Conjugation
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Unconjugated
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Modification
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Unmodified
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Form
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Liquid
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Buffer System
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Western blot analysis of PTPRC antibody in Ramos, Raw264.7 lysates using PTPRC antibody.
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Immunohistochemistry analysis of paraffin-embedded breast cancer tissues using PTPRC antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. |
Immunohistochemistry analysis of paraffin-embedded esophageal cancer tissues using PTPRC antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. |