TD-YP489016

Bentracimab(TD-YP489016) is a research-grade recombinant antibody targetingTicagrelor. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

General

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

Fab-G1-lambda

274693-27-5

Monoclonal

Ticagrelor

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

274693-27-5

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

MEDI2452, anti-ticagrelor, antidote for ticagrelor, CAS: 274693-27-5

Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor.• Ticagrelor., PMID:35396017• Ticagrelor with or without Aspirin in High-Risk Patients after PCI., PMID:31556978• Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis., PMID:38506796• Ticagrelor: clinical development and future potential., PMID:34258905• Ticagrelor resistance: a case series and algorithm for management of non-responders., PMID:34215660• Is ticagrelor worth its high cost and side-effects?, PMID:29730968• Ticagrelor in stable coronary disease., PMID:37586825• Ticagrelor-Associated Urticaria., PMID:35639409• Ticagrelor Use in Stroke Patients: Past, Present, and Future., PMID:34163168• Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial., PMID:32334703

SDS-PAGE for Research Grade Bentracimab

For research use only. Not suitable for clinical or therapeutic use.