TD-VK632036

Mazorelvimab(TD-VK632036) is a research-grade recombinant antibody targetingG. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Rabies virus (RABV)

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1, kappa

Monoclonal

G, Glycoprotein

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

O92284, P08667

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

CTB012, CTB-012, CTB012, SYN023, CAS: 2419087-89-9

Mazorelvimab (SYN023) is a combination of CTB011 and CTB012 humanized monoclonal antibodies cocktail against rabies virus (RABV). Mezagitamab binds to non-overlapping epitopes on RABV glycoprotein (G). Mezagitamab has potential application in the prevention of rabies.• The glycoprotein G of rhabdoviruses., PMID:7605197• Chandipura viral glycoprotein (CNV-G) promotes Gectosome generation and enables delivery of intracellular therapeutics., PMID:38702887• The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism., PMID:32937107• Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins?, PMID:15933774• G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates., PMID:21693135• Structure and Dynamics of Immunoglobulin G Glycoproteins., PMID:30484251• Chemical-Synthesis-Based Approach to Glycoprotein Functions in the Endoplasmic Reticulum., PMID:33107166• Human metapneumovirus glycoprotein G disrupts mitochondrial signaling in airway epithelial cells., PMID:23626834• Boronic acid functionalized g-C3N4nanosheets for ultrasensitive and selective sensing of glycoprotein in the physiological environment., PMID:29480294• 4'-(8-(4-Methylimidazole)-octyloxy)-arctigenin: The first inhibitor of fish rhabdovirus glycoprotein., PMID:37385462

SDS-PAGE for Research Grade Mazorelvimab

For research use only. Not suitable for clinical or therapeutic use.