TD-VK617016

Suvizumab(TD-VK617016) is a research-grade recombinant antibody targetingenv/Env polyprotein. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human immunodeficiency virus 1 (HIV-1)

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1, kappa

Monoclonal

env/Env polyprotein

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P03377

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

KD-247, 914257-21-9

Suvizumab (KD-247) is an neutralizing antibody anti-HIV-1. Suvizumab effectively neutralizes HIV-1MN, HIV-1SF2 and HIV-189.6 with IC50 values of 0.1 µg/mL, 1.0 µg/mL and 0.2 µg/mL, respectively. Suvizumab reduces the viral load of HIV. Suvizumab has good tolerance and can be used to prevent HIV infection.• Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4., PMID:16371160• The intracytoplasmic domain of the Env transmembrane protein is a locus for attenuation of simian immunodeficiency virus SIVmac in rhesus macaques., PMID:10846063• Differences in feline immunodeficiency virus host cell range correlate with envelope fusogenic properties., PMID:7856093• Incomplete protection, but suppression of virus burden, elicited by subunit simian immunodeficiency virus vaccines., PMID:8107246• Mechanistic analysis of pause site-dependent and -independent recombinogenic strand transfer from structurally diverse regions of the HIV genome., PMID:15342633

SEC-HPLC detection for Research Grade Suvizumab.　　|　Detects env/Env polyprotein in indirect ELISAs.　　|　SDS-PAGE for Research Grade Suvizumab.

For research use only. Not suitable for clinical or therapeutic use.