CCR8, a receptor selectively expressed on activated Tregs within tumors, plays a key role in maintaining local immunosuppression. Iv0256 is a rat-reactive CCR8 antibody with improved functional potency. In CD34 humanized mice, Iv0256 markedly reduced HCC827 lung tumor growth after intravenous administration. In syngeneic LLC and H22 models, intraperitoneal Iv0256 also achieved robust tumor suppression, displaying a pronounced dose-response pattern across tested doses.
Species reactivity
Rat
Applications
ELISA, Neutralization
Host species
Mouse
Isotype
IgG2a, kappa
Clone ID
Iv0256
Clonality
Monoclonal
Target
C-C motif chemokine receptor 8, Ccr8
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
D4ADE0
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Caption
SDS-PAGE for InVivoMAb Anti-Rat CD198/CCR8 Antibody (Iv0256)
Note
For research use only. Not suitable for clinical or therapeutic use.
抗体
试剂盒
多肽
蛋白
组织芯片
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