TD-MX139016

Astegolimab(TD-MX139016) is a research-grade recombinant antibody targetingT1. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Mouse

IgG2a-kappa

Monoclonal

T1, DER4, Interleukin-1 receptor-like 1, ST2, IL1RL1, Protein ST2

Please contact with the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q01638

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

AMG-282, MSTT-1041A, RG-6149, RO-7187807, 2173054-79-8

Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research.• T1/ST2--an IL-1 receptor-like modulator of immune responses., PMID:15110792• The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors., PMID:9794420• Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes., PMID:7556667

SDS-PAGE for Research Grade Astegolimab　　|　Detects recombinant human IL1RL1/ST2 (Catalog No:TD-HX139011) in indirect ELISA　　|　Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.Lane 1:ATGE3660 200ngLane 2:1* loading buffer

For research use only.