TD-HY596016

Natalizumab(TD-HY596016) is a research-grade recombinant antibody targetingCD49. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG4-kappa

Monoclonal

ITGA4, CD49d, CD49 antigen-like family member D, CD49D, VLA-4 subunit alpha, Integrin alpha-IV, Integrin alpha-4

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P13612

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

AN100226, BG00002, 189261-10-7

Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.

SEC-HPLC detection for Research Grade Natalizumab.　　|　SDS-PAGE for Research Grade Natalizumab　　|　Flow-cytometry using APC anti-human CD49d antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD49d monoclonal antibody (Catalog: HY596016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer. ### Flow-cytometry using FITC anti-human CD49d antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD49d monoclonal antibody (Catalog: HY596016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer. ### Flow-cytometry using PE anti-human CD49d antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD49d monoclonal antibody (Catalog: HY596016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

For research use only. Not suitable for clinical or therapeutic use.