TD-HY321016

Bersanlimab(TD-HY321016) is a research-grade recombinant antibody targetingCD54. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1-lambda

Monoclonal

ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P05362

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

BI-505, 1987854-08-9

Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.• Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation., PMID:39317271• Quercetin inhibits TNF-α induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro., PMID:32957369• ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer., PMID:34381029• The Roles of Lipoprotein in Psoriasis., PMID:32013194• Islet beta-cells and intercellular adhesion molecule-1 (ICAM-1): Integrating immune responses that influence autoimmunity and graft rejection., PMID:37619906• Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States., PMID:37062471• Systematic pan-cancer analysis insights into ICAM1 as an immunological and prognostic biomarker., PMID:38979944•Fusobacterium nucleatumpromotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis., PMID:35220887• Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions., PMID:34715236• Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane., PMID:38924997

Detects CD54/ICAM1 in indirect ELISAs.　　|　SDS-PAGE for Research Grade Bersanlimab.

For research use only. Not suitable for clinical or therapeutic use.