TD-HY195016

Apamistamab(TD-HY195016) is a research-grade recombinant antibody targetingCD45. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Mouse

IgG1-kappa

Monoclonal

T200, Leukocyte common antigen, CD45, L-CA, Receptor-type tyrosine-protein phosphatase C, PTPRC

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P08575

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Apamistamab is a monoclonal antibody developed for targeted radiotherapy in hematologic malignancies. It is commonly used in radioimmunotherapy as a carrier for radioactive isotopes, facilitating the targeted destruction of malignant cells while minimizing damage to healthy tissues. It has been studied primarily in the context of conditioning regimens for hematopoietic stem cell transplantation, particularly in treating relapsed or refractory leukemias and lymphomas.• Protein tyrosine phosphatase receptor type C (PTPRC or CD45)., PMID:34039664• Immune receptor inhibition through enforced phosphatase recruitment., PMID:33087934• Orientation-dependent CD45 inhibition with viral and engineered ligands., PMID:39454026• Innate immune remodeling by short-term intensive fasting., PMID:34705313• CD45-negative follicular lymphoma., PMID:32163561• Dynamics of Cell Generation and Turnover in the Human Heart., PMID:26073943• The Roseoloviruses Downregulate the Protein Tyrosine Phosphatase PTPRC (CD45)., PMID:33952641• CD45-PET is a robust, non-invasive tool for imaging inflammation., PMID:39843738• Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing., PMID:28262555• The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells., PMID:33990399

Detects Human CD45/PTPRC in indirect ELISAs.　　|　Flow-cytometry using anti-human CD45 antibody. Jurkat cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human CD45 monoclonal antibody (Catalog HY195016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a a Goat Anti-Mouse IgG H&L Polyclonal Antibody, FITC (abinScience: MF690414) and cells analysed on a NovoCyte Flow Cytometer.　　|　SDS-PAGE for Research Grade Apamistamab

For research use only. Not suitable for clinical or therapeutic use.