TD-HY110026

Anselamimab(TD-HY110026) is a research-grade recombinant antibody targetingSAA. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Chimeric

IgG1-kappa

Monoclonal

SAA, Serum amyloid A-1 protein, SAA1, Amyloid fibril protein AA

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P0DJI8

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

11-1F4, CAEL101, CAEL-101, NSC-711516, 2414866-63-8

Anselamimab (CAEL-101) a humanized IgG1-κ anti-Amyloid fibrils antibody targeting to serum amyloid A1 (SAA1).• Overexpression of serum amyloid a 1 induces depressive-like behavior in mice., PMID:27608955• Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2., PMID:23223242• Serum amyloid A levels are associated with polymorphic variants in the serum amyloid A 1 and 2 genes., PMID:30852808• Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera., PMID:22300576• Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis., PMID:18815155• Diversity and complexity of the mouse Saa1 and Saa2 genes., PMID:24521869• The role of PPAR activation during the systemic response to brain injury., PMID:25994490• Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A., PMID:20890286• Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice., PMID:21996012• Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7., PMID:7698755

SEC-HPLC detection for Research Grade Anselamimab.

For research use only. Not suitable for clinical or therapeutic use.