TD-HX881036

Raludotatug(TD-HX881036) is a research-grade recombinant antibody targetingK-cadherin. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1-kappa

Monoclonal

K-cadherin, CDH6, Cadherin-6, Kidney cadherin

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P55285

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

2610074-56-9

Raludotatug is a humanized immunoglobulin G1-kappa, anti-CDH6 monoclonal antibody. Raludotatug is an antineoplastic.• Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models., PMID:38205802• Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers., PMID:28526733• Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface., PMID:27563818• Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity., PMID:32600462• Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma., PMID:10940709• Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern., PMID:39182448• The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells., PMID:37523816• Cadherin 6 promotes neural crest cell detachment via F-actin regulation and influences active Rho distribution during epithelial-to-mesenchymal transition., PMID:24917505• Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons., PMID:10864459• Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway., PMID:24069422

SDS-PAGE for Research Grade Raludotatug.

For research use only. Not suitable for clinical or therapeutic use.