TD-HX243016

Benralizumab(TD-HX243016) is a research-grade recombinant antibody targetingCD125. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1-kappa

Monoclonal

IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q01344

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

BIW-8405, KHK4563, MEDI-563, 1044511-01-4

Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma.• Benralizumab for the treatment of asthma., PMID:29517082• Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma., PMID:31734469• Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)., PMID:39062845• A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease., PMID:23470716• IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans., PMID:17620072• Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output., PMID:19654410• IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils., PMID:26276876• Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression., PMID:20337967

SDS-PAGE for Research Grade Benralizumab.　　|　SEC-HPLC detection for Research Grade Benralizumab.　　|　Detects Human CD125/IL5RA in indirect ELISAs.

For research use only. Not suitable for clinical or therapeutic use.