TD-HW494036

Sulesomab(TD-HW494036) is a research-grade recombinant antibody targetingCD66. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Mouse

IgG1, kappa

Monoclonal

Normal cross-reacting antigen, Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CD66c, NCA, Non-specific crossreacting antigen

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P40199

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

IMMU-MN3, Technetium(99mTc)sulesomab, LeukoScan, 167747-19-5

Tinurilimab (Bay 1834942) is an anti-CEACAM6 monoclonal antibody. CEACAM6 is an immune checkpoint regulator suppressing the activity of effector T-cells against tumors.• Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression., PMID:29110374• Analysis of heterophilic cell adhesion mediated by CD66b and CD66c using their soluble recombinant proteins., PMID:8645267• Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)., PMID:16204051• Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas., PMID:10666389• [Nonspecific cross-reacting antigen (NCA)]., PMID:16149618• Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes., PMID:12379336• The KOR-SA3544 antigen predominantly expressed on the surface of Philadelphia chromosome-positive acute lymphoblastic leukemia cells is nonspecific cross-reacting antigen-50/90 (CD66c) and invariably expressed in cytoplasm of human leukemia cells., PMID:10374883• Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils., PMID:8543346• Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers., PMID:17201906• Bile carcinoembryonic cell adhesion molecule 6 (CEAM6) as a biomarker of malignant biliary stenoses., PMID:23806607

SDS-PAGE for Research Grade Sulesomab.　　|　Flow-cytometry using APC anti-human CD66c antibody. BXPC-3 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD66c monoclonal antibody (Catalog HW494036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer. ### Flow-cytometry using PE anti-human CD66c antibody. BXPC-3 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD66c monoclonal antibody (Catalog HW494036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer. ### Flow-cytometry using FITC anti-human CD66c antibody. BXPC-3 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD66c monoclonal antibody (Catalog HW494036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.

For research use only. Not suitable for clinical or therapeutic use.