TD-HW342066

Telazorlimab(TD-HW342066) is a research-grade recombinant antibody targetingCD134. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1-kappa

Monoclonal

ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P43489

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

GBR-830, 2126777-87-3

Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970• An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026• Entry of betaherpesviruses., PMID:31439151• OX40 (CD134) and OX40L., PMID:19760068• Research progress in OX40/OX40L in allergic diseases., PMID:39404736• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+T-cell immunity., PMID:37932534• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673

Detects CD134/TNFRSF4/OX40 in indirect ELISAs.

For research use only. Not suitable for clinical or therapeutic use.