TD-HV716016

Vixarelimab(TD-HV716016) is a research-grade recombinant antibody targetingOSMRB. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG4-IgG1, Lambda

Monoclonal

OSMRB, IL-31R subunit beta, Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31RB, IL-31R-beta, OSMR, IL-31 receptor subunit beta

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q99650

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

KPL-716, 30C6(N73D), BIIB069, BIIB-069, 2243320-83-2

Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash.• Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma., PMID:34087162• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease., PMID:28368383• Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth., PMID:34380633• Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology., PMID:26198770• The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure., PMID:35163735• Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts., PMID:38717842• Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR., PMID:38569939• AHNAK, regulated by the OSM/OSMR signaling, involved in the development of primary localized cutaneous amyloidosis., PMID:37100691• Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma., PMID:24659184• Targeting OSMR in glioma stem cells., PMID:28177884

SEC-HPLC detection for Research Grade Vixarelimab.

For research use only. Not suitable for clinical or therapeutic use.