TD-HV681016

Ontuxizumab(TD-HV681016) is a research-grade recombinant antibody targetingCD164L. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1-kappa

Monoclonal

Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q9HCU0

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

MORAb-004, 946415-62-9

Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer.• Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors., PMID:30986375• TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts., PMID:38254097• Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm., PMID:39113704• Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice., PMID:33737161• Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling., PMID:35732643• Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)., PMID:31993928• Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature., PMID:24642465• Endosialin: molecular and functional links to tumor angiogenesis., PMID:26774137• Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells., PMID:18187565• Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma., PMID:29304474

SEC-HPLC detection for Research Grade Ontuxizumab.　　|　SDS-PAGE for Research Grade Ontuxizumab.

For research use only. Not suitable for clinical or therapeutic use.