TD-HV514016

Rosmantuzumab(TD-HV514016) is a research-grade recombinant antibody targetingRSPO3. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1-kappa

Monoclonal

RSPO3, hPWTSR, hRspo3, PWTSR, R-spondin-3, Thrombospondin type-1 domain-containing protein 2, Protein with TSP type-1 repeat, Roof plate-specific spondin-3, THSD2

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q9BXY4

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

OMP-131R10, 1684393-04-1

Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors.• Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis., PMID:31348891• Hepatic stellate cells control liver zonation, size and functions via R-spondin 3., PMID:40074890• Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles., PMID:32217638• Endothelial RSPO3 mediates pulmonary endothelial regeneration by LGR4-dependent activation of β-catenin and ILK signaling pathways after inflammatory vascular injury., PMID:38677673• The role of R-spondin proteins in cancer biology., PMID:34663878• Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other., PMID:35068191• RSPO3 regulates the radioresistance of Non-Small cell lung cancer cells via NLRP3 Inflammasome-Mediated pyroptosis., PMID:39245068• R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells., PMID:31851527• R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos., PMID:24918770• RSPO3 promotes the aggressiveness of bladder cancer via Wnt/β-catenin and Hedgehog signaling pathways., PMID:30329043

SEC-HPLC detection for Research Grade Rosmantuzumab.　　|　SDS-PAGE for Research Grade Rosmantuzumab.

For research use only. Not suitable for clinical or therapeutic use.