TD-HT343066

Ramatercept(TD-HT343066) is a research-grade recombinant antibody targetingGDF-8. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Functional assay, Research in vivo

Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant)

GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

O14793

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

ACE-031, ActRIIB-IgG1, ActRIIb:FcFusionProtein, HGT-4510, RAP-031, 1169766-01-1

Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202

SDS-PAGE for Research Grade Ramatercept

For research use only. Not suitable for clinical or therapeutic use.