TD-HT343016

Landogrozumab(TD-HT343016) is a research-grade recombinant antibody targetingGDF-8. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG4-kappa

Monoclonal

GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

O14793

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

LY-2495655, 1391726-30-9

Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.• Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454• Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826• GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905• Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196• Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042• Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097• Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925• Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254• Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022• Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202

SEC-HPLC detection for Research Grade Landogrozumab.　　|　Flow-cytometry using anti-human MSTN antibody. LNCAP cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an anti-human MSTN monoclonal antibody (Catalog HT343016, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.　　|　SDS-PAGE for Research Grade Landogrozumab

For research use only. Not suitable for clinical or therapeutic use.