TD-HT009016

Nadecnemab(TD-HT009016) is a research-grade recombinant antibody targetingGFR-alpha-3. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG4-Kappa

Monoclonal

GFR-alpha-3, GDNF receptor alpha-3, GDNF family receptor alpha-3, GDNFR-alpha-3, GFRA3

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

O60609

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

REGN5069, 2377679-19-9

Nadecnemab is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab can be used for research of osteoarthritis of the knee/pain.• Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha., PMID:9535755• GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin., PMID:9740802• GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia., PMID:11745618• Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase., PMID:9608533• Glial cell line-derived neurotrophic factor is expressed in penis of adult rat and retrogradely transported in penile parasympathetic and sensory nerves., PMID:11151444• The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction., PMID:15204970

SEC-HPLC detection for Research Grade Nadecnemab.　　|　Detects GFRA3 in indirect ELISAs.

For research use only. Not suitable for clinical or therapeutic use.