TD-HS870216

Cadonilimab(TD-HS870216) is a research-grade recombinant antibody targetingCD1. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG1-kappa-[scFv-heavy-lambda]2

Monoclonal

Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279, CD152, Cytotoxic T-lymphocyte protein 4, CTLA-4, CTLA4, Cytotoxic T-lymphocyte-associated antigen 4

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q15116 & P16410

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Bispecific, AK-104, AK104, 2394841-59-7

Danvilostomig is an anti-CTLA4/PDCD1 monoclonal antibody.• Cancer immunotherapy using checkpoint blockade., PMID:29567705• The blockade of immune checkpoints in cancer immunotherapy., PMID:22437870• Immune-related adverse events of checkpoint inhibitors., PMID:32382051• Immune Checkpoint Blockade in Cancer Therapy., PMID:25605845• Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy., PMID:29256113• Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination., PMID:27141885• Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints., PMID:30184160• Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review., PMID:28945858• Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer., PMID:34088360• Fundamental Mechanisms of Immune Checkpoint Blockade Therapy., PMID:30115704

Detects Human CD152/CTLA4 in indirect ELISAs.

For research use only. Not suitable for clinical or therapeutic use.