TD-HP900016

Onfekafusp Alfa(TD-HP900016) is a research-grade recombinant antibody targetingEDB. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

[scFv-heavy-kappa-TNF(tumornecrosisfactor(TNF)superfamilymember2, TNFSF2, TNF-alpha, TNFA)]-trimer

Monoclonal

EDB, EDB-FN

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P02751-7

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

L19TNF, L19TNF-alpha, 1957239-88-1

Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research.• EDB-FN targeted probes for the surgical navigation, radionuclide imaging, and therapy of thyroid cancer., PMID:36807768• EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer., PMID:31277465• EDB-FN-targeted probes for near infrared fluorescent imaging and positron emission tomography imaging of breast cancer in mice., PMID:39333775• Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade., PMID:35793468• Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS., PMID:36049057• EDB Fibronectin-Specific SPECT Probe99mTc-HYNIC-ZD2 for Breast Cancer Detection., PMID:30023665• Tenascin-C: Form versus function., PMID:25482829• EDB Fibronectin Specific Peptide for Prostate Cancer Targeting., PMID:25848940• EDB fibronectin and angiogenesis -- a novel mechanistic pathway., PMID:16308732• RT-PCR detection of fibronectin EDA+ and EDB+ mRNA isoforms: molecular markers for hepatocellular carcinoma., PMID:7509777

SDS-PAGE for Research Grade Onfekafusp Alfa

For research use only. Not suitable for clinical or therapeutic use.