TD-HP656016

Sirtratumab(TD-HP656016) is a research-grade recombinant antibody targetingSLITRK6. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG2-kappa

Monoclonal

SLITRK6, SLIT and NTRK-like protein 6

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Q9H5Y7

Liquid

30 mM Histidine, pH5.8, 10% sucrose, 0.02% Tween80Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

AGS15C, Ha15-10ac12, Ha15-10ac12.1, 1824663-82-2

Sirtratumab is a human Igγ2 monoclonal antibody against SLIT and NTRK-like family 6 (Slitrk6). Sirtratumab can be used in research of cancer.• SLITRK6 promotes the progression of lung adenocarcinoma by regulating PI3K/AKT/mTOR signaling and Warburg effect., PMID:37219677• SLITRK6 mutations cause myopia and deafness in humans and mice., PMID:23543054• Differential expression of SLITRK6 gene as a potential therapeutic target for urothelial carcinoma in particular upper tract cancer., PMID:37353040• The role of SLITRK6 in the pathogenesis of Tourette syndrome: From the conclusion of a family-based study in the Chinese Han population., PMID:32037697• A novel mutation in SLITRK6 causes deafness and myopia in a Moroccan family., PMID:29551497• A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans., PMID:23946138• Transcriptomic Profiling Discloses Molecular and Cellular Events Related to Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells., PMID:27422411• Human cytomegalovirus downregulates SLITRK6 expression through IE2., PMID:27530937• Born This Way: Using Intrinsic Disorder to Map the Connections between SLITRKs, TSHR, and Male Sexual Orientation., PMID:30156382

Detects SLITRK6 in indirect ELISAs.　　|　SDS-PAGE for Research Grade Sirtratumab.　　|　SEC-HPLC detection for Research Grade Sirtratumab.

For research use only. Not suitable for clinical or therapeutic use.