TD-HF943026

Research Grade Gevokizumab(TD-HF943026) is ahumanized monoclonalantibody detectingInterleukin-1 betainELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable forHuman.HighlightsMulti-Application— Validated across multiple applications.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Humanized

IgG2-kappa

Human

Monoclonal

Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P01584

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

XOMA 052, 1129435-60-4

Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes.• Understanding the mechanism of IL-1β secretion., PMID:22019906• NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption., PMID:31976565• The role of IL-1β and TNF-α in intervertebral disc degeneration., PMID:32853910• Human Monocytes Engage an Alternative Inflammasome Pathway., PMID:27037191• D-mannose suppresses macrophage IL-1β production., PMID:33311467• BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity., PMID:29324233• Association of interleukin-6 and interleukin-1-β levels in patients with toxoplasmosis., PMID:35782407• Interleukin-1 beta is significantly upregulated in the decidua of spontaneous and recurrent miscarriage placentas., PMID:33545613• The effect of interleukin 1 beta blockade on the tumor microenvironment., PMID:33493144• Single-cell profiling identifies IL1Bhimacrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis., PMID:38453911

SEC-HPLC detection for Research Grade Gevokizumab.　　|　Detects Human IL1B/IL1F2 in indirect ELISAs.　　|　SDS-PAGE for Research Grade Gevokizumab.　　|　Western blot analysis was performed using anti-IL1B/IL1F2 monoclonal antibody at 1μg/ml on various samples.Lane 1:recombinant human IL1B/IL1F2 (Catalog No:TD-HF943012), 50ngLane 2:recombinant human IL1B/IL1F2 (Catalog No:TD-HF943012), 30ngLane 3:recombinant human IL1B/IL1F2 (Catalog No:TD-HF943012), 20ngLane 4:recombinant human IL1B/IL1F2 (Catalog No:TD-HF943012), 10ng

For research use only. Not suitable for clinical or therapeutic use.