TD-HF934016

Tenecteplase(TD-HF934016) is a research-grade recombinant antibody targetingt-plasminogen activator. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Functional assay, Research in vivo

Monoclonal

t-plasminogen activator, tPA, t-PA, Reteplase, Tissue-type plasminogen activator, Alteplase, PLAT

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Purified by ion exchange chromatography.

P00750

Liquid

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Tnkase, Dp00031, TNK-tPA, Metalyse, 191588-94-0

Tenecteplase, sold under the brand names Tnkase among others, is an enzyme used as a thrombolytic drug.Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.Tenecteplase was approved for medical use in the United States in June 2000.Medical usesTenecteplase is indicated to reduce the risk of death associated with acute ST elevation myocardial infarction.PharmacokineticsDistribution: approximates plasma volumeMetabolism: Primarily hepaticHalf-life elimination: Biphasic: Initial: 20–24 minutes; Terminal: 90–130 minutesExcretion: Clearance: Plasma: 99–119 mL/minuteGalleryResearchResearchers at Newcastle University in Australia say they have had a significant breakthrough in treating stroke patients using the commonly used drug. The findings were published in the New England Medical Journal. Though safety has been established through previous clinical trials, there is ongoing debate about whether this is an effective treatment for ischemic stroke, and significant ongoing discussion between emergency physicians, neurologists and pharmacists about whether this treatment should be used for that indication.The American Heart Association/American Stroke Association 2019 update to the 2018 guidelines for the Early Management of Acute Ischemic Stroke supports considering tenecteplase over alteplase in patients without contraindication to intravenous thrombolytics.References== Further reading ==

SDS-PAGE for Research Grade Tenecteplase

For research use only. Not suitable for clinical or therapeutic use.