TD-HF869016

Luspatercept(TD-HF869016) is a research-grade recombinant antibody targetingGDF11. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Functional assay, Research in vivo

Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant)

GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

O95390

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

ACE-536, luspatercept–aamt, 1373715-00-4

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.• GDF11: An emerging therapeutic target for liver diseases and fibrosis., PMID:38494851• Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth., PMID:29503194• GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells., PMID:26919250• GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling., PMID:33684566• Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11., PMID:10391213• Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11., PMID:12718768

SDS-PAGE for Research Grade Luspatercept

For research use only. Not suitable for clinical or therapeutic use.