TD-HF822016

Biciromab(TD-HF822016) is a research-grade recombinant antibody targetingFGB. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Mouse

IgG1-kappa

Monoclonal

FGB, Fibrinogen beta chain

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P02675

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Indium(111In)biciromab, T2G1, 138783-13-8

Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood. It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism, but was withdrawn during clinical trials.• A novel deletion in the fibrinogen beta chain (FGB) gene causing hypofibrinogenemia., PMID:31841708• A Novel Nonsense Mutation inFGB(c.1421G>A; p.Trp474Ter) in the Beta Chain of Fibrinogen Causing Hypofibrinogenemia with Bleeding Phenotype., PMID:33322159• Fibrinogen β chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism., PMID:34783023• Genetic Variants in theFGBandFGGGenes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype., PMID:32610551• Fibrinogen beta chain may be a potential predict biomarker for pre-eclampsia: A preliminary study., PMID:36566955• Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma., PMID:29518939• The β-Chain Mutation p.Arg17Stop Impairs Fibrinogen Synthesis and Secretion: A Nonsense Mutation Associated With Hypofibrinogenemia., PMID:39665495• Fibrinogen beta-chain -C148T polymorphism is associated with increased fibrinogen, C-reactive protein, and interleukin-6 in patients undergoing coronary artery bypass grafting., PMID:21499712• Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss., PMID:30384452• [Relationship between fibrinogen B beta gene FGB -455G/A polymorphism and atherosclerotic cerebral infarction]., PMID:15300640

SEC-HPLC detection for Research Grade Biciromab.　　|　SDS-PAGE for Research Grade Biciromab.

For research use only. Not suitable for clinical or therapeutic use.