TD-HF813016

Emapalumab(TD-HF813016) is a research-grade recombinant antibody targetingInterferon gamma. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.

Human

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Human

IgG1-lambda

Monoclonal

Interferon gamma, IFN-gamma, Immune interferon, IFNG

Please contact the lab for this information.

>95% purity as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

P01579

Liquid

0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

NI-0501, emapalumab-lzsg, 1709815-23-5

Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH).• Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation., PMID:33606996• Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy., PMID:37275859• IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption., PMID:31566580• IFN-γContributes to the Immune Mechanisms of Hypertension., PMID:36591357• Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop., PMID:33766856• Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche., PMID:29950724• IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138• Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism., PMID:29787713• Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis., PMID:37040761• MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298

SDS-PAGE for Research Grade Emapalumab.　　|　Western blot analysis was performed using anti-IFNG/IFN-gamma monoclonal antibody at 1μg/ml on various samples.Lane 1:recombinant human IFNG/IFN-gamma (Catalog No:TD-HF813012), 50ngLane 2:recombinant human IFNG/IFN-gamma (Catalog No:TD-HF813012), 30ngLane 3:recombinant human IFNG/IFN-gamma (Catalog No:TD-HF813012), 20ng

For research use only. Not suitable for clinical or therapeutic use.