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Research Grade Izalontamab
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Bioactivity
Flow cytometry
  • Catalog： TD-HF004206
  • Clonality： Monoclonal
  • Application： ELISA, Bioactivity: FACS, Functional assay, Research in vivo
  • Synonyms： Tetravalentbispecific, SI-1, SI-1X6.4, SI-B001, 2559704-24-2
  • 规格：
    询价
  • 价格：
    ¥100ug
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  • Catalog No.
    TD-HF004206
  • Description
    Izalontamab(TD-HF004206) is a research-grade recombinant antibody targetingHER1. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.
  • Species reactivity
    Human
  • Applications
    ELISA, Bioactivity: FACS, Functional assay, Research in vivo
  • Host species
    Humanized
  • Isotype
    IgG1-kappa-[scFv-heavy-lambda]2
  • Clonality
    Monoclonal
  • Target
    HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3
  • Endotoxin level
    Please contact the lab for this information.
  • Purity
    >95% purity as determined by SDS-PAGE.
  • Purification
    Protein A/G purified from cell culture supernatant.
  • Accession
    P00533 & P21860
  • Form
    Liquid
  • Storage buffer
    0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
  • Stability and Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
  • Alternate Names
    Tetravalentbispecific, SI-1, SI-1X6.4, SI-B001, 2559704-24-2
  • Background
    Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.
  • Caption
    Detects EGFR in indirect ELISA.　　|　Flow-cytometry using anti-human ERBB3 antibody. HepG2 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB3 monoclonal antibody (Catalog HF004206, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
  • Note
    For research use only. Not suitable for clinical or therapeutic use.