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抗体药类似物
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Research Grade Petosemtamab
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Bioactivity
SDS-PAGE
Flow CytoMetry
  • Catalog： TD-HF004186
  • Clonality： Monoclonal
  • Application： ELISA, Bioactivity: FACS, Functional assay, Research in vivo
  • Synonyms： Bispecific, MCLA-158, 2213450-26-9
  • 规格：
    询价
  • 价格：
    ¥100ug
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  • Catalog No.
    TD-HF004186
  • Description
    Petosemtamab(TD-HF004186) is a research-grade recombinant antibody targetingHER1. Produced in mammalian cells with native-like glycosylation.HighlightsResearch Grade— For PK/PD studies, assay development, and ADA research.Native Glycosylation— Mammalian expression ensures native-like patterns.
  • Species reactivity
    Human
  • Applications
    ELISA, Bioactivity: FACS, Functional assay, Research in vivo
  • Host species
    Human
  • Isotype
    IgG1-kappa
  • Clonality
    Monoclonal
  • Target
    HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB, G-protein coupled receptor 49, G-protein coupled receptor HG38, LGR5, GPR67, GPR49, G-protein coupled receptor 67, Leucine-rich repeat-containing G-protein coupled receptor 5
  • Endotoxin level
    Please contact the lab for this information.
  • Purity
    >95% purity as determined by SDS-PAGE.
  • Purification
    Protein A/G purified from cell culture supernatant.
  • Accession
    P00533 & O75473
  • Form
    Liquid
  • Storage buffer
    0.01M PBS, pH 7.4.Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
  • Stability and Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
  • Alternate Names
    Bispecific, MCLA-158, 2213450-26-9
  • Background
    Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC).
  • Caption
    SEC-HPLC detection for Research Grade Petosemtamab.　　|　SDS-PAGE for Research Grade Petosemtamab.　　|　Flow-cytometry using PE anti-human EGFR&LGR5 antibody. HepG-2 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human EGFR&LGR5 monoclonal antibody (Catalog: HF004186, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
  • Note
    For research use only. Not suitable for clinical or therapeutic use.