Product Name |
Margatoxin (Synonyms: 玛格斑蝎毒素) |
Cat. No. |
TD-HYP1280 |
Description |
Margatoxin 是一种 α-KTx 蝎毒素,一种高亲和力的 Kv1.3 抑制剂,Kd 为 11.7 pM。Margatoxin 抑制 Kv1.2 和 Kv1.1 通道,Kd 值分别为 6.4 pM,4.2 nM。Margatoxin 是一种 39 个氨基酸的肽,是从玛格丽特蝎 (Centruroides margaritatus) 蝎毒中分离得到的,广泛用于离子通道研究。 |
Purity |
98.44% |
CAS No. |
145808-47-5 |
分子式 |
C₁₇₈H₂₈₆N₅₂O₅₀S₇ |
分子量 |
4178.95 |
Sequence |
Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36) |
Sequence Shortening |
TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36) |
作用靶点 |
Potassium Channel |
作用通路 |
Membrane Transporter/Ion Channel |
储存方式 |
Sealed storage, away from moisture and light, under nitrogen
Powder: -80°C, 2 years;-20°C, 1 year
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |