| Catalog No. |
TD-RP11090 |
| Synonyms |
CGRP (8-37), rat |
| Description |
Calcitonin Gene Related Peptide (CGRP)(8-37) inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats. The present study was performed to explore the effect of CGRP(8-37) on the electrical stimulation-evoked discharge frequency of wide dynamic range (WDR) neurons in the dorsal horn of the spinal cord in rats. The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord. |
| Sequence |
{VAL}{THR}{HIS}{ARG}{LEU}{ALA}{GLY}{LEU}{LEU}{SER}{ARG}{SER}{GLY}{GLY}{VAL}{VAL}{LYS}{ASP}{ASN}{PHE}{VAL}{PRO}{THR}{ASN}{VAL}{GLY}{SER}{GLU}{ALA}{PHE} |
| Sequence Shortening |
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF |
| Molecular Formula |
C₁₃₈H₂₂₄N₄₂O₄₁ |
| C Terminal |
Amidation |
| Molecular Weight |
3127.6 |
| Purity |
> 95% |
| Solubility |
Soluble in Ultrapure water under 1mg/ml |
| Form |
Lyophilized |
| Storage |
Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| Note |
a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes. |