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β-Amyloid (1-42), human
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| Catalog No. | TD-RP10017 |
|---|---|
| Description | This peptide is well suited to the quantitative determination of Aβ 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (Aβ), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of Aβ peptide, Aβ 42 and Aβ 43, which have a greater tendency to aggregate than Aβ 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors. |
| Cas No | 107761-42-2 |
| Sequence | {ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}{GLY}{GLY}{VAL}{VAL}{ILE}{ALA} |
| Sequence Shortening | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Molecular Formula | C₂₀₃H₃₁₁N₅₅O₆₀S |
| Molecular Weight | 4514.1 |
| Purity | > 95% |
| Solubility | Soluble in Ultrapure water under 1mg/ml |
| Form | Lyophilized |
| Storage | Store at -20°C |
| Note | This product is a chemically-modified β-amyloid (1-42) precursor, which belongs to GenScript’s click peptides. The click peptides are best described by the following key features:1. Enhanced Stability—The O-acyl moiety within the click peptide is stable even under acidic pH.2. Convenient and quick process—The click peptides can be easily converted to native peptide at pH 7.4 or above.3. No by-product formation in the conversion process.4. Superior quality—After the click, the aggregative property of the peptides is significantly minimized compared to its native format. |