KLD-12
描述:KLD-12 是一种 12 个残基的自组装肽,可用于组织工程。KLD-12 和 SDF-1 形成自组装多肽,促进骨髓基质细胞 (BMSC) 的软骨分化。KLD-12 水凝胶可以原位填充全层骨软骨缺损,改善软骨修复。
CAS 号:800379-47-9
单字母:Ac-KLDLKLDLKLDL-CONH2
多字母:Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-CONH2
分子式:C68H122O19N16
平均分子量(MW):1467.79
精确分子量(Exact Mass)(MW):1466.91
等电点(PI):7.36
pH=7.0时的净电荷数:-
GRAVY:0.05
亲水残基比例:0.43
消光系数:-
溶解建议:亲水
参考文献:
[1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858.
[2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.