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多肽
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时间：2025-10-24
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多肽修饰服务是一种通过对多肽链进行化学修饰来改变其结构和功能的专业服务，它可以有效地改善多肽的理化性质，例如改善水溶性、增加稳定性、提高生物活性、延长体内作用时间等，还可用于标记多肽以便于检测和研究。在生物医药、生命科学研究等领域具有重要应用价值。
武汉天德拥有先进的多肽合成能力，可提供超过300种修饰类型，满足您在不同研究领域中的需求。
氨基端修饰类型 |
| BSA conjugation on N terminal -NH₂ | KLH conjugation on N terminal -NH₂ | OVA conjugation on N terminal -NH₂ | Acetylation |
| Biotin | Biotin-Ahx | 5-FAM | 5-FAM-Ahx |
| 6-FAM | 6-FAM-Ahx | 2-Abz | 4-Abz |
| Cy3 | Cy5 | Cy5.5 | Cy7 |
| DABCYL | Dansyl | Dansyl-Ahx | FITC-Ahx |
| FITC-PEG2 | 5-TMR | 6-TMR | Rhodamine B |
| MCA | 3-Maleimide | 6-Maleimide | SMCC |
| Acryl | Alloc | Benzoyl | CBZ |
| Fmoc | Br-Ac | Cl-Ac | Aminooxy |
| DOTA | NOTA | 1-Nap | 2-Nap |
| Succinylation | Glutaric acid | Butyric acid,C4 | Hexanoic acid,C6 |
| Octanoic acid,C8 | Nonanoic acid,C9 | Decanoic acid,C10 | Lauric acid,C12 |
| Myristic acid,C14 | Palmitic acid,C16 | Stearic acid,C18 | Arachidic acid,C20 |
| L-Lactic acid | D-Lactic acid | (R)-Lipoic acid | 2-Mercaptoacetic acid |
| 2-Azidoacetic acid | 4-Azidobutyric acid | 6-Azidohexanoic acid | Propiolic acid |
| 5-Hexynoic acid | Trans-Cinnamic acid | Trans-Crotonic acid | DBCO |
| Methyltetrazine | TCO |
羧基端修饰类型 |
| Amidation | Alcohol |
| AMC | Bzl |
| Cysteamide | EDA-Biotin |
| Ester (OEt) | Ester (OMe) |
| Glu(EDANS) | Hydrazine |
| MPAA | NHEt |
| Nhisopen | NHMe |
| TBzl | p-Nitroanilide |
| Tyr (3-NO₂) | BSA conjugation on C terminal -COOH |
| KLH conjugation on C terminal -COOH | OVA conjugation on C terminal -COOH |
特殊氨基酸类型 |
| {D-ALA} D-Alanine |
{pSER} Phosphorylation (SER) |
{Arg(Me)} Methylation at the side chain of Arginine |
{Arg(13C6,15N4)} Arg(13C6,15N4) |
{Beta-Ala} Beta-alanine |
| {D-ARG} D-Arginine |
{pTHR} Phosphorylation (THR) |
{SDMA} Arg(Me)2 symmetrical |
{Ile(13C6,15N)} Ile(13C6,15N) |
{GABA} 4-Aminobutyric acid |
| {D-ASN} D-Asparagine |
{pTYR} Phosphorylation (TYR) |
{ADMA} Arg(Me)2 asymmetrical |
{Leu(13C6,15N)} Leu(13C6,15N) |
{Ava} 5-Aminovaleric acid |
| {D-ASP} D-Aspartic Acid |
{d-pSER} d-pSER |
{Lys(Me)} Mono Methyl at Lys side chain |
{Lys(13C6,15N2)} Lys(13C6,15N2) |
{Ahx} 6-amino-hexanoic acid |
| {D-CYS} D-Cysteine |
{d-pTHR} d-pTHR |
{Lys(Me2)} Di Methyl at Lys side chain |
{Phe(13C9,15N)} Phe(13C9,15N) |
{Ahp} 7-Aminoheptanoic acid |
| {D-GLN} D-Glutamine |
{d-pTYR} d-pTYR |
{Lys(Me3)} Tri Methyl at Lys side chain |
{Pro(13C5,15N)} Pro(13C5,15N) |
{PEG1} NH2-(PEG)1-CH2COOH |
| {D-GLU} D-Glutamic Acid |
{Lys(N3)} Azido Lys |
{Lys-Ac} Acetylation at Lys side chain |
{Val(13C5,15N)} Val(13C5,15N) |
{PEG1-propionic acid} NH2-(PEG)1-CH2CH2COOH |
| {D-HIS} D-Histidine |
{Orn(N3)} L-azidoornithine |
{Ac-LYS} Acetylation at Lys alpha amine group |
{alpha-Me-Leu} alpha-Me-Leu |
{PEG2} NH2-(PEG)2-CH2COOH |
| {D-ILE} D-Isoleucine |
{Phe(N3)} Phe(N3) |
{D-Lys(Ac)} Acetylation at D-Lys side chain |
{alpha-Me-Lys} alpha-Me-Lys |
{PEG3} NH2-(PEG)3-CH2CH2COOH |
| {D-Allo-ILE} D-Allo-Isoleucine |
{Pra} Propargylglycine |
{Lys(biotin)} Biotin Lys |
{alpha-Me-Phe} alpha-Me-Phe |
{PEG4} NH2-(PEG)4-CH2CH2COOH |
| {D-LEU} D-Leucine |
{D-Lys(N3)} D-Lys(N3) |
{Lys(Ahx-Biotin)} Lys(Ahx-Biotin) |
{L-1-Nal} L-1-Nal |
{PEG5} NH2-(PEG)5-CH2CH2COOH |
| {D-LYS} D-Lysine |
{D-Pra} D-PROPARGYLGLYCINE |
{Lys(MCA)} Lys(7-Methoxycoumarin-4-acetic acid) |
{D-1-Nal} D-1-Nal |
{PEG6} NH2-(PEG)6-CH2CH2COOH |
| {D-MET} D-Methionine |
{Met(O)} Methionine sulfoxid |
{Lys(2-Abz)} Lys(2-Abz) |
{L-2-Nal} L-2-Nal |
{PEG8} NH2-(PEG)8-CH2CH2COOH |
| {D-PHE} D-phenylalanine |
{Met(O)2} Methionine sulfone |
{Lys(4-Abz)} Lys(4-Abz) |
{D-2-Nal} D-2-Nal |
{PEG11} NH2-(PEG)11-CH2COOH |
| {D-PRO} D-Proline |
{Se-Met} Selenomethionine |
{Lys(Dansyl)} Lys(Dansyl) |
{L-2-Pal} L-2-Pal |
{PEG12} NH2-(PEG)12-CH2CH2COOH |
| {D-SER} D-Serine |
{HomoArg} L-Homoarginine |
{Lys(5-FAM)} Lys(5-FAM) |
{D-2-Pal} D-2-Pal |
{S5} S5 |
| {D-THR} D-Threonine |
{HomoCit} L-HOMOCITRULLINE |
{Lys(6-FAM)} Lys(6-FAM) |
{L-3-Pal} L-3-Pal |
{R8} R8 |
| {D-TRP} D-Tryptophan |
{HomoCys} Homocysteine |
{Lys(FITC)} FITC at Lys side chain |
{D-3-Pal} D-3-Pal |
{Glu(EDANS)} Glu(EDANS) |
| {D-TYR} D-Tyrosine |
{HomoLeu} L-Homoleucine |
{Lys(Ahx-FITC)} Lys(Ahx-FITC) |
{L-4-Pal} L-4-Pal |
{Tyr(3-NO2)} 3-Nitro-L-tyrosine |
| {D-VAL} D-Valine |
{HomoPhe} HomoPhe |
{Lys(PEG2-FITC)} Lys(PEG2-FITC) |
{D-4-Pal} D-4-Pal |
{3-Abz} 3-Aminobenzoic acid |
| {ABU} L-alpha-aminobutyric acid |
{HomoPro}L-Homoproline | {Lys(TMR)} TMR at Lys side chain |
{L-2-F-Phe} L-2-F-Phe |
{ACC} 7-Aminocoumarin-4-Acetic acid |
| {AIB} alpha-aminoisobutyric acid (alpha-methyl-alanine) |
{HomoSer} Homoserine |
{Lys(Cy3)} Lys(Cyanine 3) |
{L-2-Cl-Phe} L-2-Chlorophe |
{MPA} MPA |
| {BPA} L-4-BENZOYLPHENYLALANINE |
{D-HomoCys} D-Homocysteine |
{Lys(Cy5)} Lys(Cyanine 5) |
{L-3-CF3-Phe} L-3-CF3-Phe |
{Beta-ASP} Beta-Aspartic Acid |
| {Cha} beta-cyclohexyl-L-alanine |
{D-HomoPhe}D-HomoPhe | {Lys(Cy7)} Lys(Cyanine 7) |
{L-3-OH-Phe} L-3-OH-Phe |
{D-Beta-Asp} D-Beta-Asp |
| {Chg} Chg |
{D-HomoSer} D-Homoserine |
{Cys(Cy3-Mal)} Cys(Cyanine 3-Maleimide) |
{L-3,4-DiCl-Phe} L-3,4-Dichlorophe |
{gamma-GLU} Gamma-GLU |
| {CIT} Citrulline |
{Beta-HomoLeu} Beta-Homoleucine |
{Cys(Cy5-Mal)} Cys(Cyanine 5-Maleimide) |
{D-3,4-DiCl-Phe} D-3,4-Dichlorophe |
{D-gamma-GLU} D-gamma-GLU |
| {Cpa} Cyclopropyl-L-alanine |
{NMe-Ala} N-methylated ALA |
{Cys(Cy7-Mal)} Cys(Cyanine 7-Maleimide) |
{L-4-F-Phe} L-4-F-Phe |
{EPSILON-LYS} EPSILON-LYS |
| {Cpg} CYCLOPENTYLGLYCINE |
{NMe-Arg} N-Methyl-L-Arginine |
{Lys(Succinic acid)} Lys(Succinic acid) |
{D-4-F-Phe} D-4-F-Phe |
{Cys(Acm)} Cys(Acm) |
| {Dab} 2,4-Diaminobutyric Acid |
{NMe-Asn} N-Methyl-L-Asparagine |
{Lys(Butyric Acid)} Lys(Butyric Acid) |
{L-4-CL-Phe} L-4-CL-Phe |
{Cys(Cam)} Carboxyamidomethylated Cysteine |
| {Dap} 2,3-Diaminopropionic Acid |
{NMe-Asp} NMe-Asp |
{Lys(Hex)} Lys(Hexanoic acid) |
{D-4-CL-Phe} D-4-CL-Phe |
{Cys(SO3)} L-Cysteic Acid |
| {DOPA}DOPA | {NMe-Cys} N-methyl-L-Cysteine |
{Lys(Oct)} Lys(Octanoic acid) |
{L-4-I-Phe} L-4-I-Phe |
{Cys(Stbu)} Cys(Stbu) |
| {HYP} Hydroxy Proline |
{NMe-Gln} N-Methyl-L-glutamine |
{Lys(Dec)} Lys(Decanoic acid) |
{D-4-I-Phe} D-4-I-Phe |
{Cys(tBu)} Cys(tBu) |
| {iso-Val} L-isovaline |
{NMe-Glu} NMe-Glu |
{Lys(Lau)} Lys(Lauric acid) |
{L-4-NO2-Phe} L-4-NO2-Phe |
{Dab(ivdde)} Dab(ivdde) |
| {J} (S)-3-Amino-3-(2-nitro-phenyl)-propionic acid |
{NMe-Gly} NMe-Gly |
{Lys(Myr)} Lys(Myristic acid) |
{D-4-NO2-Phe} D-4-NO2-Phe |
{Dap(ivdde)} Dap(ivdde) |
| {NLE} Norleucine |
{NMe-His} N-methyl-L-histidine |
{Lys(Pal)} Lys(Palmitic acid) |
{Phe(F5)} L-PENTAFLUOROPHE |
{Orn(ivdde)} Orn(ivdde) |
| {NVA} Norvaline |
{NMe-Ile} N-methylated Isoleucine |
{Lys(Ste)} Lys(Stearic acid) |
{D-Phe(F5)} D-PENTAFLUOROPHE |
{Lys(ivdde)} Lys(ivdde) |
| {Oic} L-Octahydroindole-2-Carboxylic |
{NMe-Leu} N-methylated Leucine |
{Lys(3-Mal)} Lys(3-Maleimide) |
{Phe(2-NO2)} 2-NITRO-L-PHENYLALANINE |
{D-Dab(ivdde)} D-Dab(ivdde) |
| {ORN} Ornithine |
{NMe-Lys} N-Methyl-L-Lysine |
{Lys(6-Mal)} Lys(6-Maleimide) |
{Phe(4-NO2)} 4-NITRO-L-PHENYLALANINE |
{D-Dap(ivdde)} D-Dap(ivdde) |
| {PEN} Penicillamine |
{NMe-Met} NMe-Met |
{Lys(Br-Ac)} Lys(Bromoacetyl) |
{Phe(4-NH2)} 4-Amino-L-phenylalanine |
{D-Orn(ivdde)} D-Orn(ivdde) |
| {pGLU} Pyroglutamate |
{NMe-Nle} NMe-Nle |
{Lys(Cl-Ac)} Lys(Chloroacetic acid) |
{Asp(OMe)} L-Aspartic acid 4-methyl ester |
{D-Lys(ivdde)} D-Lys(ivdde) |
| {Phg} Phenylglycine |
{NMe-Phe} N-methylated Phenylalanine |
{Lys(DOTA)} Lys(DOTA) |
{Glu(OMe)} L-Glutamic acid gamma-methyl ester |
{Asp(OAll)} Asp(OAll) |
| {Pip} L-pipecolinic acid |
{NMe-Ser} N-methylated Serine |
{Lys(NOTA)} Lys(NOTA) |
{His(1-Me)} HISTIDINE(1-ME) |
{Glu(OAll)} Glu(OAll) |
| {Tic} 1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid |
{NMe-Thr} N-methylated Threonine |
{Lys(DABCYL)} Lys(DABCYL) |
{His(3-Me)} HISTIDINE(3-ME) |
{Lys(Alloc)} Lys(Alloc) |
| {Tle} L-tert-leucine |
{NMe-Trp} N-Methyl-L-Tryptophan |
{Lys(Dnp)} Dinitrobenzylation Lys |
{Ser(Me)} Ser(Me) |
{Asp(Obzl)} L-Aspartic acid 4-benzyl ester |
| {D-Abu} (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)b |
{NMe-Tyr} N-methylated Tyrosine |
{Lys(DBCO)} Lys(DBCO) |
{Thr(Me)}Thr(Me) | {Glu(Obzl)} L-Glutamic acid-gamma-benzyl ester |
| {D-Bpa} D-P-BENZOYLPHENYLALANINE |
{NMe-Val} N-methylated Valine |
{Cys(DBCO-Mal)} Cys(DBCO-Mal) |
{Tyr(Me)} Tyr(Me) |
{D-Glu(OAll)} D-Glu(OAll) |
| {D-Cha} D-beta-cyclohexyl-L-alanine |
{NMe-Aib} N-Methyl-Alpha-Aminoisobutyric acid |
{Lys(TCO)}Lys(TCO) | {Trp(1-Me)} Trp(1-Me) |
{Ser(octanoic-acid)} Ser(octanoic-acid) |
| {D-Chg} D-Chg |
{NMe-Abu} N-Methyl-L-2-Aminobutyric acid |
{Lys(Methyltetrazine)} Lys(Methyltetrazine) |
{Trp(2-Me)} Trp(2-Me) |
{Ala(Tbu)} T-Butyl-L-Alanine |
| {D-Cit} D-Cit |
{NMe-Nva} N-Methyl-L-Norvaline |
{Cys(Methyltetrazine-Mal)} Cys(Methyltetrazine-Mal) |
{Trp(5-OH)} 5-hydroxy-L-tryptophan |
{Allyl-Gly} Allylglycine |
| {D-Cpa} D-CYCLOPROPYLALANINE |
{NMe-Tle} N-Methyl-L-tert-leucine |
{Lys(SMCC)} Lys(SMCC) |
{Trp(7-Me)} 7-methyl-L-tryptophan |
{ACBC} 1-Aminocyclobutanecarboxylic acid |
| {D-Cpg} D-CYCLOPENTYLGLYCINE |
{For-Val} N-Formyl-Valine |
{Lys(PEG2-PEG2-gamma-glu-C18DIACID)} Lys(PEG2-PEG2-gamma-glu-C18DIACID) |
{Ser(Ac)} O-Acetyl-L-Serine |
{AMPAA} 4-aminomethyl-phenylacetic acid |
| {D-Dab} D-Dab |
{For-Gly} N-Formyl-Glycine |
{Lys(PEG2-PEG2-gamma-glu-C20DIACID)} Lys(PEG2-PEG2-gamma-glu-C20DIACID) |
{Thr(Ac)} O-Acetyl-L-Threonine |
{Cycpentala} L-3-Cyclopentylalanine |
| {D-Dap} D-Dap |
{For-Met} N-Formyl-Methionine |
{Lys(Lactic acid)} Lys(Lactic acid) |
{Tyr(3-Cl)} L-3-Cl-Tyr |
{Isonipecotic Acid} Isonipecotic Acid |
| {D-NLE} D-Norleucine |
{For-Phe} N-Formyl-Phenylalanine |
{Lys(D-Lactic acid)} Lys(D-Lactic acid) |
{D-Trp(2-Me} D-Trp(2-Me) |
{3-AMBZ} 3-Aminomethylbenzoic acid |
| {D-NVA} D-Norvaline |
{For-Ala} N-Formyl-Alanine |
{Lys(Trans-Crotonic acid)} Lys(Trans-Crotonic acid) |
{D-2-Me-Trp} D-2-Me-Trp |
{4-AMBZ} 4-(Aminomethyl)benzoic acid |
| {D-ORN} D-Ornithine |
{For-Leu} N-Formyl-Leucine |
{4-APAC} (4-aminophenyl)acetic acid |
||
| {D-PEN} D-Penicillamine |
{For-Nle} N-Formyl-Norleucine |
|||
| {D-pGLU} D-Pyroglutamate |
同位素标记类型 |
| {Arg(13C6,15N4)} |
| {Ile(13C6,15N)} |
| {Leu(13C6,15N)} |
| {Lys(13C6,15N2)} |
| {Phe(13C9,15N)} |
| {Pro(13C5,15N)} |
| {Val(13C5,15N)} |
荧光修饰类型/FRET对 |
| 2-Abz (N-Terminal) | OVA conjugation on C terminal -COOH |
| 4-Abz (N-Terminal) | FITC-Ahx (N-Terminal) |
| 5-FAM (N-Terminal) | FITC-PEG2 (N-Terminal) |
| 5-FAM-Ahx (N-Terminal) | MCA (N-Terminal) |
| 6-FAM (N-Terminal) | Rhodamine B (N-Terminal) |
| 6-FAM-Ahx (N-Terminal) | AMC (C-Terminal) |
| 5-TMR (N-Terminal) | {ACC} (7-Aminocoumarin-4-Acetic acid) |
| 6-TMR (N-Terminal) | MCA/Lys(DNP) |
| Cy3 (N-Terminal) | 2-Abz/Lys(DNP) |
| Cy5 (N-Terminal) | 4-Abz/Lys(DNP) |
| Cy5.5 (N-Terminal) | 2-Abz/Tyr(3-NO2) |
| Cy7 (N-Terminal) | 4-Abz/Tyr(3-NO2) |
| Dansyl (N-Terminal) | DABCYL/Glu(EDANS) |
| Dansyl-Ahx (N-Terminal) | DABCYL/EDANS |
多肽偶联类型 |
| BSA (-COOH of C terminal) |
| BSA (-NH2 of N terminal) |
| BSA Conjugation on cysteine |
| KLH (-COOH of C terminal) |
| KLH (-NH2 of N terminal) |
| KLH Conjugation on cysteine |
| OVA (-COOH of C terminal) |
| OVA (-NH2 of N terminal) |
| OVA Conjugation on cysteine |
其他修饰类型 |
| MAPS | PEGylation | Cyclic modifications | Disulfide Bridges | Other |
| MAPS Asymmetric 2 branches (C-Terminal) | {PEG1} NH2-(PEG)1-CH2COOH |
Head to tail amide cyclic | Random Disulfide Bridge | Dimer ( Inter-Disulfide bridge) |
| MAPS Asymmetric 4 branches (C-Terminal) | {PEG1-propionic acid} NH2-PEG1-CH2CH2COOH |
Amide cyclic (Side chain) | Mono Disulfide bridge | |
| MAPS Asymmetric 8 branches (C-Terminal) | {PEG2} NH2-(PEG)2-CH2COOH |
Stapled peptide(S5/S5) | Double Disulfide bridge | |
| {PEG3} NH2-(PEG)3-CH2CH2COOH |
Stapled peptide(R8/S5) | Triple Disulfide Bridge | ||
| {PEG4} NH2-(PEG)4-CH2CH2COOH |
Mono Thioether Bridge | |||
| {PEG5} NH2-(PEG)5-CH2CH2COOH |
Thioester (C-terminal) | |||
| {PEG6} NH2-(PEG)6-CH2CH2COOH |
Amide cyclic (Head to side chain) | |||
| {PEG8} NH2-(PEG)8-CH2CH2COOH |
Amide cyclic (Side chain to tail) | |||
| {PEG11} NH2-(PEG)11-CH2COOH |
||||
| {PEG12} NH2-(PEG)12-CH2CH2COOH |